Synthesis of Actinomycetes natural products JBIR-94, JBIR-125, and related analogues
2015
Taj, Rafiq | Sorensen, John L.
The synthesis of the natural products JBIR-94, DCP, DFP, and CFP is reported. A strategy for the coupling of ferulic or coumaric acid to putrescine is described. We determined that EDCI was the most effective coupling agent for this synthesis. In addition amide coupling with saturated cinnamic acids derivatives provided the best yield. The synthesis of JBIR-125 is accomplished through a novel synthesis of differentially protected spermidine. Preliminary bioassay data demonstrated that all five compounds were active against Pseudomonas aeruginosa.
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书目信息
出版者
Elsevier B.V.
其它主题
Cinnamic acid; Natural products; Actinobacteria; Bioassays
语言
英语
类型
Journal Article; Text
2024-02-28
MODS