Acyclic Remote 1,6-Stereoselection

Reddy, Karla Janardhan; Kuilya, Tapan Kumar; Cha, Jin Kun

Acyclic Remote 1,6-Stereoselection

2022

Reddy, Karla Janardhan | Kuilya, Tapan Kumar | Cha, Jin Kun

Stereochemical communication in homopropargylation and homoallylation of aldehydes was achieved by the Ti–O temporary linker strategy. Propargylic and allylic alcohol derivatives were employed as convenient pronucleophiles, obviating prefabrication of propargylation/allylation reagents. It was surprising that 1,6-diastereoselectivity was affected by not only the Grignard reagent but also the reaction solvent.

显示更多 [+]