Fibroblast growth factor (FGF) and cytokines as feeding suppressants
1990
Oomura, Y.
The control of feeding behavior is mediated, at least in part, by chemosensitive neurons and sensor elements in the hypothalamus, medulla, liver, gut, and pancreas. In the lateral hypothalamus (LHA) there are glucose-sensitive neurons (GSN) whose activity decreases dose dependently when their plasma membrane is exposed to glucose. The activity of glucoreceptor neurons (GRN) in the ventromedial nucleus of the hypothalamus (VMH) increases when they are exposed to glucose. The responses of these GSNs and GRNs are not specific to glucose, but they also respond to free fatty acids, amino acids, intermediate metabolites, peptides, transmitters, and hormones, the levels of which are affected by hunger and satiety, and which in turn are known to affect feeding behavior. The effects of some of these substances (insulin, glucagon, calcitonin, oleic-acid, palmitic acid, serotonin, and opioids) on GSNs and GRNs have been known, for almost 20 years.
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