Circulating vitamin D metabolite concentrations in children with nutritional rickets
1983
Garabédian, Michèle | Vainsel, Marc | Mallet, Eric | Guillozo, Huguette | Toppet, Michele | Grimberg, Regine | Nguyễn, Thị Minh | Balsan, Sonia
Extract: Serum calcidiol, calcitriol, and 24,25-dihydroxyvitamin D (DHD) concentrations were measured in 20 children with vitamin D-deficiency rickets. Vitamin D metabolite concentrations were measured in 17 of 20 patients before treatment and in 14 of 20 patients after vitamin D administration. It was concluded that: before treatment, serum calcidiol seems to be the best criterion of D deficiency, as it was low (below 8 ng/ml) in 15 of 17 children studied, whereas calcitriol and DHD concentrations ranged from undetectable to high (350 pg/ml and 5.9 ng/ml, respectively) values; low calcidiol concentrations may occur despite recent vitamin D intake since low serum values were found in children given vitamin D2 up to 2 months after the onset of therapy (50 micrograms/day); elevated calcitriol serum concentrations were observed in all children after initiation of vitamin D therapy, persisting for 4 weeks or more, even after normalization of serum calcium, phosphorus, and parathyroid hormone values; healing of biochemical abnormalities can occur even in children with low circulating concentrations of calcidiol and DHD. (author/wz)
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