Optochemical control of gene expression by photocaged guanine and riboswitches

Dhamodharan, V.; Nomura, Yoko; Dwidar, Mohammed; Yokobayashi, Yohei

Optochemical control of gene expression by photocaged guanine and riboswitches

2018

Dhamodharan, V. | Nomura, Yoko | Dwidar, Mohammed | Yokobayashi, Yohei

Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.

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