Ultrasound-Promoted Synthesis of α-Thiocyanoketones via Enaminone C═C Bond Cleavage and Tunable One-Pot Access to 4-Aryl-2-aminothiazoles
2022
Liu, Yunyun | Zhang, Tao | Wan, Jie-Ping
Ultrasound has been successfully employed to promote the thiocyanation of the C═C bond in enaminones for the synthesis of α-thiocyanoketones and 2-aminothiazoles. The reactions of enaminones with ammonium thiocyanate provide α-thiocyanoketones with ultrasound irradiation at room temperature. More interestingly, simply further heating the vessel after ultrasonic irradiation leads to the selective synthesis of 2-aminothiazoles with an unconventional 4-aryl substructure.
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书目信息
出版者
Springer Netherlands
其它主题
Ammonium thiocyanate; Ambient temperature; Organic chemistry; Cleavage (chemistry)
语言
英语
类型
Journal Article; Text
2024-02-28
MODS