Indium-catalyzed C(sp³)–H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones
2015
Jamal, Zaini | Teo, Yong-Chua
The application of trivalent indium for the Lewis acid-catalyzed C(sp³)–H functionalization of 2-methylazaarenes is reported. InCl₃ was discovered to catalyze the direct addition of the benzylic C–H bond in the azaarenes to trifluoromethyl ketones. An ample number of substrates were cogently demonstrated to give the products as trifluoromethylated alcohols whereby in some cases, up to quantitative yield (99%) could be obtained.
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书目信息
出版者
John Wiley & Sons, Ltd
其它主题
Carbon-hydrogen bond activation; Chemical bonding
语言
英语
类型
Journal Article; Text
2024-02-28
MODS