Efficacy of a continuous metabolic syndrome score in Indian children for detecting subclinical atherosclerotic risk
2011
Pandit, D. | Chiplonkar, S. | Khadilkar, A. | Kinare, A. | Khadilkar, V.
Objective: To evaluate the continuous metabolic syndrome score (cMetS) in Indian children and to investigate its relationship with the risk of carotid arterial stiffness. Methods: Data on weight, height, mean arterial pressure, serum lipids, insulin, glucose, carotid intima-media thickness and stiffness parameters, that is, pulse wave velocity (PWV), elasticity modulus (Ep), stiffness index (beta) and arterial compliance (AC), were assessed in 236 children (6-17 years) from Pune city, India. cMetS was computed using standardized Z-scores for metabolic syndrome (MS) components. cMetS cutoff was obtained by receiver operating characteristic curve analysis across MS components. Results: cMetS was lowest (-3.6+/-2.0) in normal children and highest (3.3+/-2.4) in MS children. cMetS increased progressively with number of risk components. The cutoff of cMetS yielding maximal sensitivity (80%) and specificity (94%) for predicting the presence of MS was -0.8 (area under the curve=0.921 (95% CI: 0.877-0.964)). In children with cMetS above -0.8, average PWV (4.3+/-0.6 m s-1), beta (3.8+/-1.2) and Ep (50.4+/-14.5 kPa) were significantly higher than the respective values (3.7+/-0.5 m s−1; 3.4+/-0.8; 37.0+/-10.0 kPa) in children with cMetS below -0.8, whereas AC was lower (1.2+/-0.5 mm2 kPa-1) in children with cMetS above -0.8 as against AC (1.4+/-0.3 mm2 kPa-1) in children with cMetS below -0.8 (P<0.05), demonstrating the risk of stiffness with increasing score. Pearson's correlation coefficients of cMetS with PWV (r=0.575), beta (r=0.347), AC (r=−0.267) and Ep (r=0.530) were statistically significant (P<0.01).
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