New cytochalasan alkaloids and cyclobutane dimer from an endophytic fungus Cytospora chrysosperma in Hippophae rhamnoides and their antimicrobial activities
2021
Mou, Qing-Lin | Yang, Sheng-Xiang | Xiang, Ting | Liu, Wen-Wen | Yang, Jian | Guo, Lan-Ping | Wang, Wen-Jing | Yang, Xiao-Long
Three new cytochalasan alkaloids, cytochrysins A-C (1–3), and a new cyclobutane dimer, cytospodimer A (4), along with three known compounds (5–7), were isolated from the solid culture of Cytospora chrysosperma, an endophytic fungus isolated from Hippophae rhamnoides. Their structures were determined by a combination of spectroscopy and single-crystal X-ray crystallography. Compound 1 showed significant antibacterial activity against multi-drug resistant Enterococcus faecium with an MIC value of 25 μg/mL, and compound 3 against methicillin-resistant Staphylococcus aureus with an MIC value of 25 μg/mL.
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