Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
2014
Carneiro, Miguel | Rubin, Carl-Johan | Di Palma, Federica | Albert, Frank W. | Alföldi, Jessica | Barrio, Alvaro Martinez | Pielberg, Gerli | Rafati, Nima | Sayyab, Shumaila | Turner-Maier, Jason | Younis, Shady | Afonso, Sandra | Aken, Bronwen | Alves, Joel M. | Barrell, Daniel | Bolet, Gerard | Boucher, Samuel | Burbano, Hernán A. | Campos, Rita | Chang, Jean L. | Duranthon, Veronique | Fontanesi, Luca | Garreau, Hervé | Heiman, David | Johnson, Jeremy | Mage, Rose G. | Peng, Ze | Queney, Guillaume | Rogel-Gaillard, Claire | Ruffier, Magali | Searle, Steve | Villafuerte, Rafael | Xiong, Anqi | Young, Sarah | Forsberg-Nilsson, Karin | Good, Jeffrey M. | Lander, Eric S. | Ferrand, Nuno | Lindblad-Toh, Kerstin | Andersson, Leif
Rabbits softly swept to domestication When people domesticate animals, they select for tameness and tolerance of humans. What else do they look for? To identify the selective pressures that led to rabbit domestication, Carneiro et al. sequenced a domestic rabbit genome and compared it to that of its wild brethren (see the Perspective by Lohmueller). Domestication did not involve a single gene changing, but rather many gene alleles changing in frequency between tame and domestic rabbits, known as a soft selective sweep. Many of these alleles have changes that may affect brain development, supporting the idea that tameness involves changes at multiple loci. Science , this issue p. 1074; see also p. 1000
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