A new butenolide derivative from the deep-sea fungus Aspergillus terreus SCSIO FZQ028
2020
Zeng, Qi | Zhong, Wei-Mao | Chen, Yu-Chan | Xiang, Yao | Chen, Xia-Yu | Tian, Xin-Peng | Zhang, Wei-Min | Zhang, Si | Wang, Fa-Zuo
A new butenolide derivative (±)-asperteretal F (1) and related congener (2) recently reported containing an unusual 2-benzyl-3-phenyl substituted lactone core, together with five known compounds (3–7) were isolated and characterized from the fungus Aspergillus terreus. SCSIO FZQ028 derived from a deep-sea sediment of South China Sea. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, and HR-ESI-MS analysis. Additionally, all the compounds were evaluated for the antioxidative activities against DPPH, cytotoxic activities against two tumor cell lines (SF-268 and HepG-2), and antimicrobial activities. Compounds 2-4, and 7 showed significant activities against DPPH with IC₅₀ ranging from 5.89 to 10.07 μg/mL. Compounds 2 and 4 showed moderate antimicrobial activities against all four tested bacteria.
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