Coherent Anti-Stokes Raman Scattering Microspectroscopic Kinetic Study of Fast Hydrogen Bond Formation in Microfluidic Devices
2013
Oshovsky, Gennady V. | Rago, Gianluca | Day, James P. R. | Soudijn, Maarten L. | Rock, William | Parekh, Sapun H. | Ciancaleoni, Gianluca | Reek, Joost N. H. | Bonn, Mischa
The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine–hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d₂ were determined to be k₁ > 10⁵ M–¹s–¹ and k–₁ > 333.3 s–¹, respectively.
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