Vitamin D: new perspectives
1987
A brief technical review summarizes and discusses the growing evidence that the vitamin D endocrine system is involved in the modulation of a number of basic cellular processes as well as in the regulation of bone and mineral metabolism. This evidence indicates that: (1) 1,25-dihydroxyvitamin D3 (1,25-DHD3) is a potent bone resorbing agent but only has an indirect effect on osteoclasts; (2) immunocytochemical studies have revealed numerous potential target organs for 1,25-DHD3 (including brain, kidney, liver, skin, reproductive tissues, hormone secreting glands, and certain immune system cells); and (3) 1,25-DHD3 may have a role in controlling cell proliferation and differentiation for cancer inhibition. It is noted that a generalized mechanism of action of 1,25-DHD3 in such a diversity of cell types remains to be developed.(wz)
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