Vitamin K status and parenteral nutrition; the effect of Intralipid on plasma vitamin K1 levels
1994
Drittj-Reijnders, M.J. | Sels, J.P. | Rouflart, M. | Thijssen, H.H.W.
Parenteral nutrition may affect the patient's vitamin K status. This imposes a risk when using drugs that interfere with the vitamin K-dependent clotting factor synthesis, such as N-methyl-thiotetrazole-containing cephalosporins. Intravenous lipid emulsions based on plant oils may contain phylloquinone (vitamin K1). We estimated the vitamin K1 content of the intravenous lipid emulsion product Intralipid (20%), an emulsion based on soybean oil, and estimated the vitamin K1 status of recipient patients. The emulsion was found to contain 0.6-0.7 microgram/ml of the vitamin. Patients supplied with the product per continuous intravenous infusion, showed a steady increase of their plasma vitamin K1 levels, 3-30-fold over 4 days of infusion. In conclusion, the study shows that fat emulsions prepared from plant oils may contain vitamin K, in sufficient amounts to meet the daily requirement.
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