Regioselective synthesis of the 4,5-dialkoxy-2-nitroanilines bearing two different alkoxy substituents
2022
Grolik, Jarosław | Ręka, Paweł | Gorczyca, Magdalena | Stadnicka, Katarzyna
This article reports the regioselective and chemoselective synthesis of 4,5-dialkoxy-2-nitroanilines substituted with two alkoxys at C-4 and C-5. Here we show the optimization protocol of the transetherification reaction used to synthesize 20 new compounds with good to excellent yields (50–92%). We describe a simple and efficient one-step procedure that can be applied to obtain a significant number of pharmacologically active compounds, including antimalarial drug Primaquine analogs.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Elsevier Ltd
其它主题
Chemoselectivity; 2-nitroaniline; Chemoselectivity; Aromatic nucleophilic substitution; Antimalarials; Transetherification; Regioselectivity; Regioselectivity
语言
英语
许可
//data.crossref.org/schemas/AccessIndicators.xsd:license_ref>http://purl.org/eprint/accessRights/OpenAccess | //data.crossref.org/schemas/AccessIndicators.xsd:program>//data.crossref.org/schemas/AccessIndicators.xsd:license_ref> | //data.crossref.org/schemas/AccessIndicators.xsd:program>
类型
Journal Article; Text
2024-02-28
MODS