Postprandial hormonal responses to different types of complex carbohydrate in individuals with impaired glucose tolerance
1980
Crapo, Phyllis A. | Kolterman, Orville G. | Waldeck, Nancy | Reaven, Gerald M. | Olefsky, Jerrold M.
Postprandial plasma glucose, insulin and glucagon were measured in 11 subjects with impaired glucose tolerance following oral carbohydrate loads of 50 g of glucose from different sources. These included dextrose, rice, potato, corn and bread. Glucose response to rice and bread was lower than response to dextrose and potato; corn elicited an intermediate response. Insulin response to rice was also lower than to dextrose and potato, with bread and corn intermediate. Both dextrose and all four kinds of dietary starch suppressed glucagon; dextrose, however, caused the greatest suppression. These findings demonstrate that glucose-intolerant individuals exhibit a range of glucose, insulin and glucagon responses to different complex carbohydrates. It is suggested that differences in plasma glucose response may be useful in hyperglycemia therapy. Differences in postprandial responses are magnified in subjects who are less efficient in metabolizing glucose. Thus, diets enriched in less glucogenic starches may be therapeutic in diabetics.
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