Suspected swainsonine poisoning in a Belgian horse
2008
Nollet, H. | Panter, K. | Vanschandevijl, K. | Lefere, L. | Stegelmeier, B. | Deprez, P.
The case of a horse with acute symptoms of excitement, exaggerated fright reactions and trembling is presented. In addition to these cerebral symptoms, mild cerebellar ataxia and a renal tubular lesion were diagnosed. Suspected swainsonine poisoning was confirmed by the presence of the toxin (154 ng/ml) in the serum sample taken immediately after admission. A good recovery was seen after fluid therapy with supplementation of potassium, a dopamine drip and administration of diazepam. The effects of the toxin, by inhibiting the lysosomal enzyme α-mannosidase and mimicking the genetic mannosidosis, are discussed.
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