Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37
2020
Noppawan, Somchai | Mongkolthanaruk, Wiyada | Suwannasai, Nuttika | Senawong, Thanaset | Moontragoon, Pairot | Boonmak, Jaursup | Youngme, Sujittra | McCloskey, Sirirath
A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC₅₀ = 19.60 µg/mL), HT29 (IC₅₀ = 17.31 µg/mL), HCT116 (IC₅₀ = 14.28 µg/mL), MCF-7 (IC₅₀ = 15.38 µg/mL), and Vero (IC₅₀ = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines.
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