Penetration, excretion and metabolism of 14C malathion in susceptible and resistant strains of Plutella xylostella
1992
Doichuanngam, K. | Thornhill, R.A.
The rate of penetration 14C malathion into the larvae of the diamondback moth, Plutella xylostella L., was found to be significantly different in an R-strain and S-strain. The rate of penetration was more rapid in the R-strain during the first hour after treatment. The rate of metabolism in vivo and the rate of excretion were also higher in the R-strain compared with the S-strain. The main metabolites produced in both strains were malathion dicarboxylic acid and desmethyl malathion. The mechanism of insecticide resistance in Plutella xylostella L. is multifactorial, and involves a higher rate of penetration into the larvae of the R-strain, a higher activity of enzymes involved in its metabolism, and a higher level of excretion of the toxic compounds from the body of the R-strain compared with the S-strain.
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