Highly regioselective C-5 alkynylation of imidazoles by one-pot sequential bromination and Sonogashira cross coupling
2015
Bellina, Fabio | Lessi, Marco | Marianetti, Giulia | Panattoni, Alessandro
A variety of 2-substituted 5-alkynyl-1H-imidazoles were easily prepared by a one-pot sequential procedure involving a highly regioselective electrophilic C-5 bromination of 1,2-dimethyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, and 2-aryl-1-methyl-1H-imidazoles, followed by an efficient palladium/copper co-catalyzed Sonogashira-type alkynylation.
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书目信息
出版者
Elsevier Ltd
其它主题
Alkynylation; Sonogashira reaction; Lewis acids; Aromatic bromination; Bromination; Regioselectivity; Regioselectivity
语言
英语
类型
Journal Article; Text
2024-02-28
MODS