The study of the possible metabolic pathway of cis-cinnamic acid in rat liver
2003
Sun, F.M.
The results from in vitro studies of the metabolism of cis-cinnamic acid by rat liver cell-free homogenate with 4-pentenoic acid suggest that this isomerization reaction is the first step in the metabolism of cis-cinnamic acid by rat liver. This finding suggests that an isomerase is constitutively present in rat liver to catalyze the transformation reaction of cis-cinnamic acid to trans-cinnamic acid. The trans-cinnamic acid formed from cis-cinnamic acid was then catabolized by a cycle of beta-oxidation to form benzoyl-CoA. More than 75% of this resultant benzoyl-CoA was conjugated with glycine to produce hippuric acid, suggesting this pathway is the major route for rat liver to catabolize cis-cinnamic acid. A pathway for the metabolism of cis-cinnamic acid in rat liver is proposed based on this data.
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