The beneficial effects of dietary grape supplementation on improving cognitive deficits in APP/PS1 double transgenic mice
2018
Sheng, Kangliang | Shui, Shanshan | Yan, Ling | Yu, Junjie | Hao, Guang | Qu, Hao | Liu, Jian | Zhang, Yan | Liu, Changhong | Zheng, Lei
Alzheimer's disease (AD) is characterized by a progressive neurodegenerative disorder and there is no effective treatment to delay disease progression. Our study was to examine potential protection mechanisms by administering 2% grape powder or 2% grape powder modified by high hydrostatic pressure (HHP) diets to APP/PS1 mice for 24 weeks. The grape supplementation altered APP processing by increasing ADAM10 expression and reducing BACE1 and PS1 expression in the hippocampus and cerebral cortex, which therefore improved cognitive deficits in mice. The levels of TNF-α and IL-1β were remarkably decreased in serum and hippocampus by grape supplementation. Furthermore, there was a significant enhancement of SOD activities and reduction of MDA levels in the hippocampus of APP/PS1 mice treated with grape supplementation. Our findings indicated that grape supplementation could be an effective approach for AD intervention, which might be associated with altering APP processing, inhibiting inflammation responses, and enhancing antioxidant capacity.
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