Synthesis and Enzymatic Evaluation of Nucleosides Derived from 5-Iodo-2’-Halo-2’-Deoxyuridines
2014
Kniess, Torsten | Grote, Michaela | Noll, Bernhard | Johannsen, Bernd
The synthesis of new nucleosides by alkenylation of 5-iodo-2’-halo-2’-deoxyuridines with E-(1-tributylstannyl)-propene-1-ol via STILLE-coupling is described. The new compounds are characterized by ¹H NMR and elemental analysis. All nucleosides are evaluated by an enzymatic assay to be substrates of herpes simplex virus type 1 thymidine kinase (HSV-1 TK) and compared with uridine, thymidine and (E)-5-(2-iodovinyl)-2’-fluoro-2’-deoxyuridine (IVFRU).
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书目信息
出版者
Verlag der Zeitschrift für Naturforschung
其它主题
Human alphaherpesvirus 1; 5-iodo-deoxyuridines; Stille-coupling; Thymidine kinase; Hsv-1 thymidine kinase; Human herpesvirus 1
语言
英语
注释
2019-12-06
类型
Journal Article; Text
2024-02-28
MODS