Biocompatibility of a nanocomposite based on Aerosil 380 and carboxylated fullerene C60[C(COOH)2]3
2021
Sharoyko, Vladimir V. | Iurev, Gleb O. | Postnov, Viktor N. | Meshcheriakov, Anatolii A. | Ageev, Sergei V. | Ivanova, Daria A. | Petrov, Andrey V. | Luttsev, Michail D. | Nashchekin, Alexei V. | Iamalova, Nailia R. | Vasina, Lubov V. | Solovtsova, Irina L. | Murin, Igor V. | Semenov, Konstantin N.
Silica is silicon dioxide, which, depending on the production method, can exist in various amorphous forms with varying specific surface area, particle size, pore volume and size, and, as a result, with different physicochemical and sorption characteristics. The presence of silanol groups on the surface of silicas provides the possibility of its further functionalisation. In addition, the developed specific surface of Aerosil allows to obtain composites with a high content of biologically active substances. In this work, we studied the biocompatibility of a composite based on Aerosil 380 and carboxylated fullerene C₆₀[C(COOH)₂]₃, namely: haemolysis (spontaneous and photoinduced), platelet aggregation, binding to HSA, cyto- and genotoxicity, antiradical activity. Interest in the creation of this nanomaterial is due to the fact that carboxylated fullerenes have potential applications in various fields of biomedicine, including the ability to bind reactive oxygen species, inhibition of tumour development, inactivation of viruses and bacteria. The obtained composite can be used for the immobilisation of various drugs and the further development of drugs for theranostics.
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