Pectin supplementation in rats mitigates age‐related impairment in insulin and leptin sensitivity independently of reducing food intake
2015
Palou, Mariona | Sánchez, Juana | García‐Carrizo, Francisco | Palou, Andreu | Picó, Catalina
SCOPE: This study investigates whether pectin supplementation in adult rats can ameliorate age‐associated disturbances in peripheral insulin and leptin actions. METHODS AND RESULTS: Seven‐month‐old male Wistar rats were divided into three groups: control (rats fed ad libitum a standard‐diet), pectin (rats fed ad libitum a standard‐diet supplemented with 10% pectin), and pair‐fed (rats pair‐fed to the pectin group). They were sacrificed after 1 month. Pectin and pair‐fed rats showed lower body weight gain and food intake than controls and underwent a decrease in leptin levels and an increase in adiponectin levels. Pectin‐treated animals, but not pair‐fed ones, showed lower body‐fat content and HOMA‐IR index after dietary intervention. Compared to controls, pectin‐treated rats showed a decline in the expression of genes related to energy uptake (WAT) and lipogenesis (WAT and liver), and increased expression levels of lipolysis‐ and fatty‐acid oxidation‐related genes (liver). Some of the changes were not evidenced in the pair‐fed group. These effects appear to be associated with improved leptin signaling. CONCLUSION: Ten percent pectin supplementation for 1 month in adult rats decreases body‐fat content and ameliorates age‐related insulin and leptin resistance more intensely than what could be attributed to the decrease in energy intake, overall contributing to better metabolic health.
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