Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor
2012
Davis, Tyler A. | Danneman, Michael W. | Johnston, Jeffrey N.
The first enantioselective synthesis of a potent GlyT1 inhibitor is described. A 3-nitroazetidine donor is used in an enantioselective aza-Henry reaction catalyzed by a bis(amidine)-triflic acid salt organocatalyst, delivering the key intermediate with 92% ee. This adduct is reductively denitrated and converted to the target through a short sequence, thereby allowing assignment of the absolute configuration of the more potent enantiomer.
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书目信息
出版者
The Royal Society of Chemistry
其它主题
Enantioselectivity; Nitroalkanes; Organocatalysts; Enantiomers; Enantioselective synthesis; Chemical communication
语言
英语
许可
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类型
Journal Article; Text
2024-02-28
MODS