Pharmacokinetic profile of plasma tocopherol following intramuscular administration of acetylated alpha-tocopherol to sheep
1996
Hidiroglou, M.
Five sheep, with a mean BW of 45 kg, were given a single i.m. injection (600 IU) of dl-alpha-tocopherol acetate. Plasma concentration of alpha-tocopherol was best fitted to a single-compartment model. Two successive absorption processes were selected. The individual pharmacokinetic parameters were absorption rate constant, Ka1 = 0.29 +/- 0.02/h; the second absorption rate constant, Ka2 = 0.03 +/- 0.002/h; elimination half- life = 42.40 +/- 1.70/h; mean residence time = 46 +/- 0.92 h; and area under the curve = 290 +/- 10.77 microgram/h per ml. During the first absorption process, elimination half-life was 2.46 +/- 0.22 h, and the second elimination half-life was 21.20 +/- 1.72 h. The peak concentration of vitamin E plasma (4.78 +/- 0.23 microgram/ml) was observed at 14.6 +/- 4.08 h after i.m. injection. The increase in vitamin E concentration occurred because of gradual hepatic hydrolysis of the absorbed acetylated tocopherol.
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