Nickel deprivation in rats: Nickel-iron interactions
1979
Nielsen, Forrest H. | Zimmerman, Thomas J. | Collings, Michael E. | Myron, Duane R.
Pregnant rats were fed diets containing 10 to 16 ng of nickel/g of diet. Dietary iron was supplied in various amounts as either ferric chloride or ferric sulfate. Controls were given a supplemental 20 micrograms of nickel/g of diet. Severe iron deficiency appeared to be more detrimental to the nickel-supplemented than to deficient rats whose growth was more severely depressed. However, when dietary iron was only borderline deficient, or adequate, nickel-deprived rats did not perform as well as nickel-supplemented controls. The number and severity of the signs of nickel deprivation increased when dietary iron was supplied at 60 micrograms/g of diet as ferric sulfate instead of 30 micrograms/g as ferric chloride. The iron status of the rat may influence the extent and severity of the signs of nickel deprivation.
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