A thermodynamic theory of codon bias in viral genes
1983
Rowe, G.W. | Trainor, L.E.H.
The relationship between degeneracy in the genetic code and the occurrence of a strong condon bias is examined, with particular reference to a group of viral genomes. The present paper shows how codon bias may have been imposed by thermodynamic considerations at the time the primitive DNA first formed in the primordial soup. Using a four-state Ising-like model with stacking interactions between successive base pairs, we show how primeval periodic DNA polymers could have arisen the remnants of which are still observed in codon biases today.
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书目信息
其它主题
Genetic; Correlation analysis; Messenger; Codon usage; Base pair stacking; Viral; Viral; Base sequence; Base composition; Nucleotide sequences; Dna conformation; Genome; Dna stacking
语言
英语
注释
2019-12-04
类型
Journal Article; Text
2024-02-28
MODS