Effects of volume expansion and contraction on potassium homeostasis in normal and hypertensive humans
1986
Luft, F.C. | Weinberger, M.H. | Grim, C.E. | Fineberg, N.S.
A variety of parameters were analyzed to investigate the effects of potassium on blood pressure in 431 normotensive and 478 hypertensive subjects of different ages, races, and sexes. White normotensive subjects had significantly higher levels of serum and urinary potassium, and fractional potassium excretion. Black subjects had higher urinary sodium:potassium ratios. These racial differences were less consistent among the hypertensive subjects. There was a significant correlation between urinary sodium:potassium ratio and blood pressure in normal subjects; there was a significant inverse relationship between serum potassium and blood pressure in the hypertensive group. The data indicate that urinary potassium excretion is influenced by age, race, sex, body weight, blood pressure, creatinine clearance, renin, and aldosterone.(lsp)
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