Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells
1983
Farley, John R. | Wergedal, Jon E. | Baylink, David J.
Studies of in vitro and in vivo treatment of chick bone cells with fluoride (F) indicated that: the proliferation rate of the bone cells was increased (measured by tritiated-thymidine (3HT) incorporation); the alkaline phosphatase (ALP) level was increased; and the growth and mineralization of embryonic bone was enhanced. Since F increased bone cell number and ALP activity in vivo, the results suggest that the increased bone formation seen with F occurs (at least partially) from direct effects on bone cells. It also was determined that the effects of F on 3HT incorporation can be moderated by parathyroid hormone and by human skeletal growth factor. (wz)
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