Terpenoids from the Root Bark of Pterolobium macropterum

Suthiwong, Jittra; Pitchuanchom, Siripit; Wattanawongdon, Wareeporn; Hahnvajanawong, Chariya; Yenjai, Chavi

Terpenoids from the Root Bark of Pterolobium macropterum

2014

Suthiwong, Jittra | Pitchuanchom, Siripit | Wattanawongdon, Wareeporn | Hahnvajanawong, Chariya | Yenjai, Chavi

Five new compounds, including pteroloterins A–C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC₅₀ value of 23.24 ± 0.18 μM and showed no activity against normal cells.

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