Hypoalbuminaemia in acute phase response is not related to depressed albumin synthesis: experimental evidence in magnesium-deficient rat
2002
Nassir, Fatiha | Zimowska, Wioletta | Bayle, Dominique | Gueux, Elyett | Rayssiguier, Yves | Mazur, Andrzei
Studies conducted on laboratory animals have clearly established that dietary magnesium (Mg) deficiency leads to aninflammatory process, that might participate in pathological consequences of this deficiency. Several alterations in plasma biochemistry have been described in Mg-deficient animals and the pattern appears to relate to the inflammatory acute phase response. The present study provides experimental evidence that acute phase response caused by Mg deficiency in the rat leads to hypoalbuminaemia. Thus underlying mechanism for the observed hypoalbuminaemia in Mg-deficient rats was studied in the present work. Our results show that total protein and albumin syntheses in the liver were not affected by Mg-deficiency. Because the capacity of the liver to synthesize albumin appears to be maintained the observed hypoalbuminaemia could be due to an increase in catabolism or the escape of this protein from the plasma pool in to the extra-vascular space.
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