La ghréline et ses analogues dans le traitement de l’anorexie et de la cachexie cancéreuse
2022
Raynard, Bruno | Hen, Nathalie Ho Hio | Guinhut, Marie | Chemama, Stéphanie
Ghrelin is one of the appetite-stimulating neuro-hormones. It also participates in regulation of energy expenditure and muscle anabolism. It intervenes in the digestive motricity. Its secretion by the stomach and its action on hypothalamus could be altered by pro-inflammatory cytokines during cancer cachexia. Ghrelin supplementation in animal models of cancer cachexia partly reverses these phenomena, and improves energy intake and muscle mass. This beneficial effect is not found in humans. Anamorelin, a ghrelin analogue, which can be administered orally, has been tested in cachectic patients. Anamorelin improves muscle mass and appetite but has no effect on muscle function and survival. The combination of anamorelin, dietary counseling and physical activity could be more effective on functional status and quality of life. Multimodal and early management including ghrelin or one of its analogues must be evaluated in large randomized controlled trials.
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