New eudesmane sesquiterpenes from the marine-derived fungus Penicillium thomii
2015
Afiyatullov, Shamil Sh | Leshchenko, Elena V. | Sobolevskaya, Maria P. | Denisenko, Vladimir A. | Kirichuk, Natalya N. | Khudyakova, Yuliya V. | Hoai, Trinh P.T. | Dmitrenok, Pavel S. | Menchinskaya, Ekaterina S. | Pislyagin, Еvgeny А | Berdyshev, Dmitrii V.
Four new eudesmane-type sesquiterpenes thomimarines A–D (1–4) were isolated from the marine-derived fungus Penicillium thomii. Their structures were established based on spectroscopic methods. The absolute configurations of 1–4 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Inhibitory effects of compounds 1, 2 and 4 on NO production in LPS-induced RAW 264.7 murine macrophages were evaluated.
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