TBA reactive material in human plasma and its relation to nutritional parameters
1989
Ursini, F. | Maiani, G. | Polito, A. | Coassin, M. | Ferro-Luzzi, A.
The level of lipid peroxidation in the plasma of 270 subjects aged 65 yrs and over was determined using as index of the amount of peroxidation products thiobarbituric acid reactive material (TBA-RM). The mean plasma concentration of TBA-RM was 2.84 +/- 0.90 nmol/ml. The relationship between lipid peroxidation and plasma antioxidant level showed that only retinols are inversely correlated with TBA-RM, while tocopherols and carotenoids are positively correlated. These results suggested further analysis to fit a working hypothesis. In a homogeneous subsample of the subjects we studied the content in plasma lipids of the conjugate diene derivative of linoleic acid (18 : 2-9, 11). While linear regression analysis did not show a statistically significant negative correlation between 18 : 2-9, 11 and tocopherols, a highly significant positive correlation with retinols was observed. A tentative interpretative scheme is presented where, following the formation of carbon centred radicals and reversible oxygen addition, the peroxidative chain reaction is stopped at the level of hydroperoxy radicals or at the level of carbon centred radicals by either vitamin E or vitamin A, respectively. The highly significative correlation between the ratios 9,11/TBA-RM and tocopherols/retinols seems to support the hypothesis.
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