Effect of palmitic, linoleic and α-linolenic acids on blood cells count and interleukin-4, 8 genes expression in lambs experimentally infected with foot and mouth disease virus
2022
Adibnia, Saba | Zarei, Abolfazl | Sadeghi, Ali-Asghar | Chamani, Mohammad
The current research was conducted to study the effects of different saturated and poly-unsaturated fatty acid sources in diets on immune responses of lambs experimentally infected with foot and mouth disease virus. A total of fifteen Sangsari male lambs with an average body weight of 48 ± 2 kg and an average age of 8 ± 1 months were randomly allocated to one of three experimental treatments: (1) PalOil group received a calcium soap of palm oil fatty acids in the diet as source of palmitic acid (16:0), (2) SunOil group received a calcium soap of sunflower oil fatty acids in the diet as source of linoleic acid (n-6 18:2), and (3) LinOil group received a calcium soap of linseed oil fatty acids in the diet as source of α-linolenic acid (n-3 18:3). The greatestand the least expression of IL-4 mRNA were measured in SunOil and LinOil groups, respectively. Expression of IL-8 mRNA was greater in SunOil treatment when compared with PalOil and LinOil groups. In conclusion, the results of the study confirmed that inclusion of α-linolenic acid in virally infected lambs’diet results in lower expression of IL-4 and IL-8 mRNA.
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