On the Reaction of Methylmercuric Hydroxide with Methylcobalamin

Chu, Victor C. W.; Gruenwedel, Dieter W.

On the Reaction of Methylmercuric Hydroxide with Methylcobalamin

2014

Chu, Victor C. W. | Gruenwedel, Dieter W.

The methylmercury-induced dealkylation of the corrinoid coenzyme methylcobalamin, yielding aquocobalamin and dimethylmercury as products, was studied spectrophotometri-cally at 350 nm using water as a solvent. Rate data were determined for the pH 7-9 region and also at pH 3.37. Evidence is provided which shows that CH₃Hg⁺ serves as the species which accepts the methyl group and also that Hg²⁺ is methylated more rapidly than CH₃Hg⁺ is.

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