Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore

Jiang, Xue; Wang, Meining; Song, Shanshan; Xu, Youjun; Miao, Zehong; Zhang, Ao

Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore

2015

A simple and more effective four-step synthesis of the tricyclic quinone–pyran–lactone skeleton was developed. Subsequent structural modification led to several series of derivatives. Regio- and diastereo-characteristics of these compounds were elucidated, and their antitumor activities against several cancer cells were investigated.

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