Production of pharmaceutical materials using genetically modified plants grown under artificial lighting
2011
Goto, E.
Recently, genetically modified (GM) plants have attracted much attention because of their use in the production of valuable materials, such as pharmaceutical proteins, for humans or livestock. Pharmaceutical products that have been or are being developed include oral vaccines for humans or livestock and agents that prevent lifestyle-related diseases. A closed plant production system is ideal for the propagation of medicinal products. We developed a closed plant production system with artificial lighting for stable accumulation of high concentrations of desired functional proteins in the edible components of strawberry and rice plants. The GM strawberry plant accumulates a functional protein in the achenes and the fruit, which is known to prevent lifestyle-related diseases. The GM rice plant accumulates an oral vaccine in the protein body of the seed. Because responses of GM plants to environmental conditions have not been investigated, we researched the physiological characteristics of plants under artificial conditions; this included the effects of light quality, light intensity, light period, ultraviolet stress, low temperature stress, carbon dioxide concentration, composition and concentration of nutrient solution, and planting density. First, we determined the appropriate environmental conditions for optimizing rice and strawberry plant production of valuable materials in large quantities.
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