NaCl-induced arterial hypertension in rats: Effect of varying the corn oil content of the diet
1981
Mogenson, Gordon J. | Morris, Paul | Box, Blanche
A 10% corn oil diet containing 7.5% NaCl significantly increased arterial blood pressure within 17 days in normotensive adult male rats. Animals could be classified as hypertensive-prone or hypertensive-resistant, depending on the rate of increase. NaCl was eliminated from the diet after 1 month and the corn oil content was varied. A 1.7% decrease in the level of corn oil in diets fed the hypertensive-prone animals caused a further increase in blood pressure and a significant increase in potassium excretion. Normotensive male weanling rats also developed significantly elevated arterial blood pressure in 6 weeks on a diet of either 8 or 17% corn oil containing 3.75% NaCl; after 6 weeks, animals fed the higher level of corn oil maintained significantly lower blood pressures, and after 14 weeks these rats exhibited significantly greater potassium excretion. These studies demonstrate that salt-induced hypertension, as well as electrolyte balance, is affected by the level of dietary corn oil. These effects may be associated with prostaglandin synthesis, as corn oil is a good source of linoleic acid, a prostaglandin precursor.
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