Effect of the visual environment on proteins and peptides in the developing brain of the fly, Boettcherisca peregrina
1993
Mimura, K.
Deprivation of fight during the early Post-emergence period of the fly retards the functional development of the visual system and results in loss of normal pattern discrimination. A previous study using HPLC demonstrated a transient increase of two kinds of biogenic amines and related substances during the early after emergence period in flies reared in a visually rich environment. The results of the present study in which HPLC was used to analyse proteins and peptides are as follows: (1) Twelve of the 21 substances contained in the brain were dependent on visual experience. (2) One of these showed a transient increase without regard to region of the brain during the first few days after emergence in dark-reared Hies but not in light/dark-reared flies. (3) One of the other substances showed a very delayed, pronounced increase in light/dark-reared flies. The increase occurred from the 11th day after emergence and persisted without regard to the regions of the brain. (4) It is concluded that the brain contains proteins and peptides dependent on visual experience, which show plastic development, and that the deprivation of visual stimulation produces a compensatory increase in two kinds of substances.
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