Elevated phenylalanine concentrations in benign hyperphenylalaninemia from evaporated milk feedings
1993
Miller, M.E. | Plumeau, P. | Blakely, E.
Benign hyperphenylalaninemia is a common cause of elevated blood phenylalanine concentrations detected in newborn screening programs in which blood phenylalanine levels remain in the range of 2 to 12 mg/dL and no phenylalanine restriction in the diet is needed. We evaluated a male infant who was diagnosed with benign hyperphenylalaninemia and demonstrated blood phenylalanine concentrations above 12 mg/dl after being started on formula. He had an older sister who also had been diagnosed as having benign hyperphenylalaninemia and who had also developed significantly elevated blood phenylalanine concentrations up to 20 mg/dl. Further inquiry into the feeding histories of the children revealed that the mother was feeding them partially diluted evaporated milk, which has a significantly greater phenylalanine content than either breast milk or infant formula. This was probably the cause of the unexpectedly high phenylalanine concentrations in these siblings after infant feedings were begun.
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