Efficacy of a moxidectin/triclabendazole oral formulation against mixed infections of Fasciola hepatica and gastrointestinal nematodes in sheep
2010
Martínez-Valladares, M. | Cordero-Pérez, C. | Castañón-Ordóñez, L. | Famularo, M.R. | Fernández-Pato, N. | Rojo-Vázquez, F.A.
We have evaluated the efficacy in sheep of a combination drench formulation at the recommended dose rate of 0.2mgmoxidectin/kg bodyweight and 10mgtriclabendazole/kg bodyweight against an experimental infection with Fasciola hepatica and a natural infection with gastrointestinal nematodes. We confirmed that the efficacy of reducing fecal egg output was 98.3% for trichostrongyle eggs and 100% for F. hepatica eggs. Based on adult worm and fluke recovery, the efficacy varied according to the target species. A reduction was found in the number of Teladorsagia circumcincta, Trichostrongylus spp., Nematodirus spp., and Trichuris spp. greater than 95%, but the efficacy for Oesophagostomum spp. varied, with values below 90%. The reduction in F. hepatica was higher than 95% for all stages. The effectiveness of the formulation was also confirmed by an increase in total proteins and albumin following treatment.
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