Recombinant derivatives of Pasteurella multocida toxin: candidates for a vaccine against progressive atrophic rhinitis
1991
Petersen, S.K. | Foged, N.T. | Bording, A. | Nielsen, J.P. | Riemann, H.K. | Frandsen, P.L.
Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a lack of toxic activity. One such component was shown to induce efficient protection of vaccinated female mice and their offspring against challenge with purified P. multocida toxin.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
其它主题
Prevention & control; Synthetic; Inbred balb c; Bacterial vaccines; Isolation & purification; Swine diseases; Atrophic; Female; Amino acid sequence; Structural genes; Deletions; Epitopes; Chromosome deletion; Structure-activity relationship; Veterinary; Derivatives
语言
英语
类型
Journal Article; Text
2024-02-28
MODS