Studies on the mechanism of the Cadogan–Sundberg indole synthesis

Majgier-Baranowska, Helena; Williams, John D.; Li, Bing; Peet, Norton P.

Studies on the mechanism of the Cadogan–Sundberg indole synthesis

2012

Majgier-Baranowska, Helena | Williams, John D. | Li, Bing | Peet, Norton P.

The Cadogan–Sundberg indole synthesis produces two major products from the treatment of 2-nitrostilbenes with triethyl phosphite, which are the 2-arylindoles and the corresponding 2-aryl-N-ethoxyindoles. We were interested in determining the origin of the oxygen atom in the 2-aryl-N-ethoxyindoles. In this study, we verify that this oxygen atom originates from the nitro group and not from the triethyl phosphite.

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