Antiviral activity of lignans and their glycosides from Justicia procumbens
1996
Asano, J. | Chiba, K. | Tada, M. | Yoshi, T.
Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1 respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 microgram ml-1, respectively) against cultured rabbit lung cells (RL-33).
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