Schistosoma bovis: vaccine effects of a recombinant homologous glutathione S-transferase in sheep
1999
Boulanger, D. | Schneider, D. | Chippaux, J.P. | Sellin, B. | Capron, A.
The economic importance of the nematode Schistosoma bovis in African livestock has justified the development of a specific vaccine. Administered preventively to sheep, rSb28GST--the only molecule cloned from S. bovis which has demonstrated vaccine potentialities in goats and cattle--reduced the mean worm burden in vaccinated animals and improved their health status compared with that of non-vaccinated controls. As in goats, but not in bovines, the fecundity of the settled worm pairs was not modified. Therefore, rSb28GST can be proposed as a universal tool for the prevention of clinical disorders engendered by the main schistosome species affecting domestic ruminants in the African continent.
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