Synthesis of α-Trifluoromethylacrylates by Ligand-Free Palladium-Catalyzed Mizoroki-Heck Reaction
2019
Xiao, Pan | Schlinquer, Claire | Pannecoucke, Xavier | Bouillon, Jean-Philippe | Couve-Bonnaire, Samuel
Efficient ligand-free palladium catalyzed Mizoroki–Heck reaction allowed the formation of trisubstituted α-trifluoromethylacrylates. The reaction showed good chemical tolerance and furnished moderate to excellent yields of reaction. Silver salt additive proved to be essential for the reaction. The reaction has been then applied to the formation of 3-trifluoromethyl coumarins and analogues of therapeutic agents.
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书目信息
Journal of organic chemistry
卷
84
期
4
页码
2072
- 2082
ISSN
1520-6904
出版者
American Chemical Society
其它主题
Biological resistance; Organic chemistry; Therapeutics
语言
英语
类型
Journal Article; Text
2024-02-28
MODS