Flavonoid delivery by solid dispersion: a systematic review
2022
Colombo, Mariana | Michels, Luana Roberta | Teixeira, Helder Ferreira | Koester, Letícia Scherer
The poor water solubility of flavonoids represents the greatest challenge to increasing the oral bioavailability of these compounds. Nevertheless, several potential positive effects of flavonoids have been demonstrated by many studies and therefore much attention has been given to developing ways to improve solubility, such as solid dispersions (SD). However, there is no review evaluating the general impact of the use of SD on flavonoids. Thus, this review aims to present a detailed analysis of the current literature which used the SD approach to ameliorate the solubility, dissolution, and oral bioavailability parameters of flavonoids for use in future research. Most studies adopted the solvent evaporation method and polyvinylpyrrolidone was the most common carrier used. In general, the studies concluded that SD developed by different methods using different carriers are an excellent alternative to improve solubility, dissolution and significantly increase the oral bioavailability of subclasses of flavonoids.
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